Zanaflex prescribing information

The wide range of effectively acting doses of medication Zanaflex (from 2mg up to 36mg Zanaflex per day), allows using this neuromuscular blocking agent for both short and long-term treatment courses of pain syndromes, muscle spasms and seizures.

Zanaflex can be used as monotherapy. However, if muscle spasms and pain syndrome are caused by inflammation of the muscle tissue, Zanaflex is prescribed in combination with non-steroidal anti-inflammatory drugs (NSAIDs).

By keeping the recommendations for use Zanaflex, one can improve the clinical efficiency of medication Zanaflex as well as significantly reduce the risk of side effects of Zanaflex.

In general medical practice (rheumatology, orthopedics, traumatology, sports medicine), Zanaflex drug is used for the treatment of pain syndromes, occurring in muscle tissue due to:

• excessive load on skeletal-muscle system (neck pain, tension headache, back pain);
• degenerative and/or inflammatory diseases of the spinal cord (spondylitis, arthritis);
• post-surgical complications (in spinal cord, upper and lower limb girdle);
• muscle tissue injury with the direct impact or open fracture;
• neurological disorders (multiple sclerosis, traumatic brain injury).

It is recommended to start with minimal doses of Zanaflex, as side effects occurrence directly depends on the daily dose of Zanaflex drug. When starting the treatment with a minimum daily dose of Zanaflex 2mg or Zanaflex 4mg and watching for body reactions, the development and intensity of side effects can be controlled independently.

By increasing the dose size Zanaflex, one can prevent side effects and overdose Zanaflex little by little, as well as adjust the optimal daily dose of Zanaflex, which can be even lower than a standard one.

After the long-term usage of medication Zanaflex (especially in large doses), one should reject using the drug gradually. A sharp refusal of Zanaflex pills may cause the muscle weakness. The occurrence of muscle weakness is typical for all the neuromuscular blocking agents. But in comparison with Baclofen and Diazepam, the development of muscle weakness because of Zanaflex use, is much less common.

One of the side effects of Zanaflex pills 2mg and Zanaflex 4mg is increased sleepiness (hypersomnia). Taking into account that in most cases muscle seizures are accompanied by the pain syndrome, which may lead to sleep disorder, a sedative effect of Zanaflex may be used as a means for improving the sleep quality.

Dosage Zanaflex for insomnia is appointed to each case individually. Those people, whose professional activity or social behavior is connected to high concentration and quick response, should divide the daily dose of Zanaflex into 2 intakes. Taking ½ daily dose Zanaflex in the afternoon and ½ Zanaflex dose before sleep, allows to preserve the normal social behavior and improve the night sleep regimen.

In order to achieve a maximal therapeutic effect, patient should take the pills Zanaflex 2mg or Zanaflex 4mg, combining them with non-steroidal anti-inflammatory drugs (NSAIDs).

Advil (Ibuprofen) is more preferred NSAID for combination therapy. The combined use of Zanaflex and Advil (Ibuprofen):

• enhances the effectiveness of treatment;
• allows to use Zanaflex and Advil (Ibuprofen) in smaller doses;
• has got gastroprotective effect, increasing the protective function of the gastric mucosa.

The  usage of Zanaflex 2mg or Zanaflex 4mg causes a moderate reduction of blood pressure. The simultaneous use of Zanaflex pills with antihypertensive drugs, enhances the anti-hypertensive effect. In the treatment of post-stroke spasticity, a hypotensive effect of Zanaflex tablets may be used either to reduce the dose of antihypertensive drugs, or to stop the anti-hypertensive therapy, conducted before.

The use of Zanaflex 2mg or Zanaflex 4mg pills may be only justified in case, when the additional neuromuscular blocking agent supplements the pharmacological properties of Zanaflex in complex therapy.

The application of the tablets Zanaflex 2mg or Zanaflex 4mg in combination with antidepressants may cause the increased impact of antidepressant on the function of central nervous system. Please, read the information on drug interaction of antidepressant and neuromuscular blocking agent Zanaflex, before you start taking antidepressants together with Zanaflex pills.

Generic Zanaflex is the pharmacological analogue of brand Zanaflex, produced on the basis of an active substance Tizanidine. The amount of Tizanidine in a single pill of generic Zanaflex is exactly the same as in brand Zanaflex. Therefore these both drugs has an equal pharmacological effect and accordingly are to be taken in equal doses.

• One tablet of generic Zanaflex 2mg contains Tizanidine 2mg (equivalent to brand Zanaflex)
• One tablet of generic Zanaflex 4mg contains Tizanidine 4mg (equivalent to brand Zanaflex 4mg)
• One pill of generic Zanaflex 6mg contains Tizanidine 6mg respectively (equivalent to brand Zanaflex 6mg)

Generic Zanaflex is cheaper than brand Zanaflex only because Indian producers of generic Zanaflex never invested multi-million investments to the development of the active substance Tizanidine. So, Indian manufacturers of generic Zanaflex are eligible to set their acceptable prices for their products due to the lack of expenses for the invention of Tizanidine. As a result, the price for generic Zanaflex may be 2-3 times lower than for brand Zanaflex.

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The maximum concentration of the active component Tizanidine in the blood is 1 hour after generic Zanaflex intake. Therefore the maximum degree of side effects severity coincides with this period of time.

The most frequently observed side effects of generic Zanaflex 2mg and brand Zanaflex 4mg are: sleepiness, dizziness and dryness in mouth. In prolonged use of generic Zanaflex 2mg or brand Zanaflex 4mg, side effects are temporal, causing no serious damage of the mental or physical state.

Elderly people and patients with chronic liver or kidney dysfunction should be very careful, when using generic Zanaflex. Generic Zanaflex is appointed in minimal doses to this category of patients.

It’s not recommended to use Zanaflex during pregnancy, as Tizanidine negatively affects the fetal development. Generic Zanaflex 2mg or brand Zanaflex 4mg can be only taken during pregnancy under the constant supervision of a doctor and only in case of threat to the life of mother and fetus.

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